Xanthomata

Xanthoma refers to a condition where fatty deposits build up under the skin, forming yellowish bumps or plaques. These deposits are made of cholesterol and can develop anywhere on the body but commonly appear on areas like elbows, knees, hands, feet, or buttocks. Xanthomas are typically painless but can be indicative of underlying health issues, such as high cholesterol, diabetes, and cholestatic liver disease.

Hypercholesterolaemia [1]
HIV infection [2]
Hepatitis C [3]
Gastric cancer (gastric xanthoma) [4]
Oestrogens
Tamoxifen (estrogen modulator in breast cancer treatment)
Oral retinoids
Prednisolone
Ciclosporin [1]
Medical procedures like organ transplants may require medications that may indirectly contribute to xanthoma formation
Cerebrotendinous xanthomatosis [5]
Diabetes mellitus
Insulin resistance [1]
Frequent mechanical trauma
- Achilles heel xanthomas in type II class of hypercholesterolemia [6]
Cholestatic liver disease
Nephrotic syndrome
Hypercholesterolemia [1]